Effects of Intra-Aortic Balloon Pump Timing on Baroreflex Activities in a Closed-Loop Cardiovascular Hybrid Model

Despite 50 years of research to assess the intra-aortic balloon pump (IABP) effects on patients' hemodynamics, some issues related to the effects of this therapy are still not fully understood. One of these issues is the effect of IABP, its inflation timing and duration on peripheral circulation autonomic controls. This work provides a systematic analysis of IABP effects on baroreflex using a cardiovascular hybrid model, which consists of computational and hydraulic submodels. The work also included a baroreflex computational model that was connected to a hydraulic model with a 40-cm3 balloon. The IABP was operated at different inflation trigger timings (0.14 to 0.31s) and inflation durations (0.050.45s), with time of the dicrotic notch being taken as t=0. Baroreflex-dependent parametersafferent and efferent pathway activity, heart rate, peripheral resistance, and venous tonewere evaluated at each of the inflation trigger times and durations considered. Balloon early inflation (0.09s before the dicrotic notch) with inflation duration of 0.25s generated a maximum net increment of afferent pathway activity of 10%, thus leading to a decrement of efferent sympathetic activity by 15.3% compared with baseline values. These times also resulted in a reduction in peripheral resistance and heart rate by 4 and 4.3% compared with baseline value. We conclude that optimum IABP triggering time results in positive effects on peripheral circulation autonomic controls. Conversely, if the balloon is not properly timed, peripheral resistance and heart rate may even increase, which could lead to detrimental outcomes.