A short, efficient and high-yielding approach for the diastereoselective syntheses of the four (5'S)- and (5'R)-5',8-cyclopurine lesions and their phosphoramidites has been developed. The intermediates prepared by these synthetic pathways provide an easy access to those modified nucleosides that constitute an important molecular library for recognition of DNA damage. With respect to previous synthesis, the key methodologies for cyclization steps and phosphoramidite synthesis were ameliorated.
Problem solving approach for the diastereoselective synthesis of (5'S)-and (5'R)-5',8 cyclopurine lesions
Chryssostomos Chatgilialoglu;Annalisa Masi;Anna Sansone;
2014
Abstract
A short, efficient and high-yielding approach for the diastereoselective syntheses of the four (5'S)- and (5'R)-5',8-cyclopurine lesions and their phosphoramidites has been developed. The intermediates prepared by these synthetic pathways provide an easy access to those modified nucleosides that constitute an important molecular library for recognition of DNA damage. With respect to previous synthesis, the key methodologies for cyclization steps and phosphoramidite synthesis were ameliorated.File in questo prodotto:
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