Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats

Extracts of kidney beans (Phaseolus vulgaris) are known to reduce food intake and glycemia in rodents and humans. This study evaluated the effect of a novel extract of Phaseolus vulgaris on food (regular food pellets, starch-enriched diet, and chocolate-flavoured beverage) intake, body weight, and glycemia in rats. The effect of the combination of the colecistokinin (CCK) receptor antagonist, lorglumide, and Phaseolus vulgaris dry extract on food intake was also investigated. Administration of doses of Phaseolus vulgaris dry extract devoid of any behavioral toxicity dose-dependently decreased food intake (irrespective of the diet), body weight gain, and glycemia. Pretreatment with lorglumide blocked the reducing effect of Phaseolus vulgaris dry extract on food intake. The capacity of this Phaseolus vulgaris dry extract to reduce food intake, body weight, and glycemia in rats may be due to (a) inhibition of ?-amylase, (b) stimulation of CCK release from the intestinal brush border cells, and/or (c) interference with the central mechanism(s) regulating appetite, food intake, and food palatability.