The contribution of chemical steps in trasduction chains to the output noise of a receptor cell (as opposed to the noise inherent in the stimulus, e.g., a dim light flash) has been evaluated both analytically and by a computer simulation study on a simple model, using a Monte Carlo technique. The noise deriving from chemical reactions (chemical shot noise, CSN) is shown to add to the source noise thereby increasing significantly the output variation coefficient. It is proposed that this noise contribution should be taken into account in interpreting the sensitivity of a sensory system and in particular the dose-response curves at low levels of the stimulus.
FUNDAMENTAL SOURCES OF NOISE IN SENSORY TRANSDUCTION
LUCIA S;
1995
Abstract
The contribution of chemical steps in trasduction chains to the output noise of a receptor cell (as opposed to the noise inherent in the stimulus, e.g., a dim light flash) has been evaluated both analytically and by a computer simulation study on a simple model, using a Monte Carlo technique. The noise deriving from chemical reactions (chemical shot noise, CSN) is shown to add to the source noise thereby increasing significantly the output variation coefficient. It is proposed that this noise contribution should be taken into account in interpreting the sensitivity of a sensory system and in particular the dose-response curves at low levels of the stimulus.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.