The contribution of chemical steps in trasduction chains to the output noise of a receptor cell (as opposed to the noise inherent in the stimulus, e.g., a dim light flash) has been evaluated both analytically and by a computer simulation study on a simple model, using a Monte Carlo technique. The noise deriving from chemical reactions (chemical shot noise, CSN) is shown to add to the source noise thereby increasing significantly the output variation coefficient. It is proposed that this noise contribution should be taken into account in interpreting the sensitivity of a sensory system and in particular the dose-response curves at low levels of the stimulus.

FUNDAMENTAL SOURCES OF NOISE IN SENSORY TRANSDUCTION

LUCIA S;
1995

Abstract

The contribution of chemical steps in trasduction chains to the output noise of a receptor cell (as opposed to the noise inherent in the stimulus, e.g., a dim light flash) has been evaluated both analytically and by a computer simulation study on a simple model, using a Monte Carlo technique. The noise deriving from chemical reactions (chemical shot noise, CSN) is shown to add to the source noise thereby increasing significantly the output variation coefficient. It is proposed that this noise contribution should be taken into account in interpreting the sensitivity of a sensory system and in particular the dose-response curves at low levels of the stimulus.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/285607
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