Background: The single-nucleotide polymorphism T300A of ATG16L1, a Crohn's disease (CD)-associated gene, is responsible for decreased autophagy. This study aimed to investigate the effects of this single-nucleotide polymorphism on the uptake and processing of antigens by dendritic cells (DCs) and the interaction between DC and intestinal epithelium in pediatric patients with CD.

T300A Variant of Autophagy ATG16L1 Gene is Associated with Decreased Antigen Sampling and Processing by Dendritic Cells in Pediatric Crohn's Disease

Camarca Alessandra;Gianfrani Carmela
2013

Abstract

Background: The single-nucleotide polymorphism T300A of ATG16L1, a Crohn's disease (CD)-associated gene, is responsible for decreased autophagy. This study aimed to investigate the effects of this single-nucleotide polymorphism on the uptake and processing of antigens by dendritic cells (DCs) and the interaction between DC and intestinal epithelium in pediatric patients with CD.
2013
Istituto di Biochimica delle Proteine - IBP - Sede Napoli
Istituto di Scienze dell'Alimentazione - ISA
Istituto di Biochimica e Biologia Cellulare - IBBC
autophagy
Crohn's disease
immunity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/286494
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