Potentiometric and spectroscopic data including CD and EPR results as well as theoretical calculations have shown that the insertion of the tetrazole ring [-psi (CN4)-] in the tetraalanine sequence leads to a very effective peptide chelating agent towards Cu(II) ions. The [-psi (CN4)-] moiety induces a specific peptide conformation which favours the formation of one or two stable chelating rings stabilising a bent structure, with the coordination of 1N-type in Cut or 3N-type in both CuH-1L and CuH-2L species. It is worth noting that the Cu(II)-N-tetr bond does not undergo the hydrolysis process even at high pH although the N-tetr donor is weakly basic.
A new class of peptide chelating agents towards copper(II) ions
D Sanna;
2001
Abstract
Potentiometric and spectroscopic data including CD and EPR results as well as theoretical calculations have shown that the insertion of the tetrazole ring [-psi (CN4)-] in the tetraalanine sequence leads to a very effective peptide chelating agent towards Cu(II) ions. The [-psi (CN4)-] moiety induces a specific peptide conformation which favours the formation of one or two stable chelating rings stabilising a bent structure, with the coordination of 1N-type in Cut or 3N-type in both CuH-1L and CuH-2L species. It is worth noting that the Cu(II)-N-tetr bond does not undergo the hydrolysis process even at high pH although the N-tetr donor is weakly basic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
