Photodynamic therapy (PDT) can take advantage of the properties of non-linear optical phenomena, namely increased spatial confinement of the treatment and deeper penetration in tissues by the NIR excitation source. Hence, the search for two photon (TP) absorbers with PDT properties is an active and challenging research area. [1] We report here on the design, synthesis and characterization of diketopyrrolopyrrole-zinc porphyrin conjugates designed as sensitizers for TP-PDT. One of the studied molecules is reported in Figure 1. The conjugates show two order of magnitude higher TP absorption cross-section with respect to the parent porphyrin and preserve a significantly high yield of singlet oxygen production (Figure 1). [2] Two-photon induced phototoxicity, tested on cell culture, showed above 90% of cell death. The exploration of novel derivatives containing a Gd complex as TP-theranostic agents will be briefly presented. Acknowledgements icFRC, Région Alsace, CNR PM.P04.010, PRIN 2010CX2TLM, Nanomax N-CHEM and ESF-EUROCORES 10-EuroSolarFuels-FP-006.
Photophysics of diketopyrrolopyrrole-porphyrin conjugates designed for two-photon photodynamic therapy
Barbara Ventura;Lucia Flamigni;
2015
Abstract
Photodynamic therapy (PDT) can take advantage of the properties of non-linear optical phenomena, namely increased spatial confinement of the treatment and deeper penetration in tissues by the NIR excitation source. Hence, the search for two photon (TP) absorbers with PDT properties is an active and challenging research area. [1] We report here on the design, synthesis and characterization of diketopyrrolopyrrole-zinc porphyrin conjugates designed as sensitizers for TP-PDT. One of the studied molecules is reported in Figure 1. The conjugates show two order of magnitude higher TP absorption cross-section with respect to the parent porphyrin and preserve a significantly high yield of singlet oxygen production (Figure 1). [2] Two-photon induced phototoxicity, tested on cell culture, showed above 90% of cell death. The exploration of novel derivatives containing a Gd complex as TP-theranostic agents will be briefly presented. Acknowledgements icFRC, Région Alsace, CNR PM.P04.010, PRIN 2010CX2TLM, Nanomax N-CHEM and ESF-EUROCORES 10-EuroSolarFuels-FP-006.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
