Polycondensation of a nitrogen mustard carbonate analogue with aromatic diols under dilution conditions affords a series of azacrown ethers previously not easily accessible as they require multistep synthesis including protection, purification, cyclization and methylation. This novel synthesis relies upon the anchimeric effect of the nitrogen mustard carbonate and it does not require the use of any base.
Azacrown Ethers from Mustard Carbonate Analogues
Crisma Marco;
2015
Abstract
Polycondensation of a nitrogen mustard carbonate analogue with aromatic diols under dilution conditions affords a series of azacrown ethers previously not easily accessible as they require multistep synthesis including protection, purification, cyclization and methylation. This novel synthesis relies upon the anchimeric effect of the nitrogen mustard carbonate and it does not require the use of any base.File in questo prodotto:
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