In the brain, amyloid precursor protein (APP) and amyloid beta are critical in the pathogenesis of Alzheimer's Disease (AD), which is the most common form of dementia in the elderly. We recently demonstrated by gain and loss of function experiments, that miR-101 is a negative regulator of APP expression and Amyloid beta load in primary rat hippocampal neurons. We are planning to investigate the role of miR-101 in the regulation of amyyloid precursor protein and in the onset and progression of AD by using established primary cell cultures and AD murine models.
MicroRNAs in neurodegenerative diseases
Francesca Ruberti;
2010
Abstract
In the brain, amyloid precursor protein (APP) and amyloid beta are critical in the pathogenesis of Alzheimer's Disease (AD), which is the most common form of dementia in the elderly. We recently demonstrated by gain and loss of function experiments, that miR-101 is a negative regulator of APP expression and Amyloid beta load in primary rat hippocampal neurons. We are planning to investigate the role of miR-101 in the regulation of amyyloid precursor protein and in the onset and progression of AD by using established primary cell cultures and AD murine models.File in questo prodotto:
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