An improved and efficient electrochem. N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addn. of base or probase, by direct electrolysis of a soln. of MeCN-TEAP contg. the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products, e.g., I, were isolated in high to excellent yields.
Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones.2
2002
Abstract
An improved and efficient electrochem. N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addn. of base or probase, by direct electrolysis of a soln. of MeCN-TEAP contg. the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products, e.g., I, were isolated in high to excellent yields.File in questo prodotto:
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