The aim of this study is to investigate the effect of a non-invasive physical treatment on activated microglia of a well-established mouse model of Parkinson disease (PD), based on intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To this aim, we proposed a Radio electric asymmetric conveyer (REAC) technology, with its specific therapeutic protocols of regenerative medicine: tissue optimization - regenerative (TO-RGN), as an innovative therapeutic strategy for the treatment of PD. We observed that REAC TO-RGN exposition can attenuate the damage of nigrostriatal pathway induced by MPTP treatment in mice, decreasing levels of pro-inflammatory mediators in the substantia nigra pars compacta (SNpc) of MPTP-mice. Besides, TH immunostaining in MPTP-treated mice exposed to REAC TO-RGN resulted more pronounced in both substantia nigra and striatum in comparison to animals that received only MPTP treatment. Overall, these data suggest that REAC TO-RGN treatment can have neuroprotective effects in MPTP-induced PD mice model, which may be related to reduced inflammatory reaction.
Modulation of pro-inflammatory response in a mouse model of Parkinson's disease by non-invasive physical approach
Alessandra Aloisi;Rosaria Rinaldi;
2015
Abstract
The aim of this study is to investigate the effect of a non-invasive physical treatment on activated microglia of a well-established mouse model of Parkinson disease (PD), based on intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). To this aim, we proposed a Radio electric asymmetric conveyer (REAC) technology, with its specific therapeutic protocols of regenerative medicine: tissue optimization - regenerative (TO-RGN), as an innovative therapeutic strategy for the treatment of PD. We observed that REAC TO-RGN exposition can attenuate the damage of nigrostriatal pathway induced by MPTP treatment in mice, decreasing levels of pro-inflammatory mediators in the substantia nigra pars compacta (SNpc) of MPTP-mice. Besides, TH immunostaining in MPTP-treated mice exposed to REAC TO-RGN resulted more pronounced in both substantia nigra and striatum in comparison to animals that received only MPTP treatment. Overall, these data suggest that REAC TO-RGN treatment can have neuroprotective effects in MPTP-induced PD mice model, which may be related to reduced inflammatory reaction.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
