Anticancer activities of anthocyanin extract from genotyped Solanum tuberosum L. "Vitelotte"

The action of anthocyanins contained in the Vitelotte potato (Solanum tuberosum L.) in bothbreast and haematological cancers were investigated. The biomedical activities of anthocyaninextract derived from the Vitelotte cultivar were determined. Molecular genotypingwas performed to properly identify this outstanding genotype in comparison to other potatovarieties and to promote the utilization of this genetic resource by plant breeders. Furthermore,cellular and molecular characterization of the action of anthocyanin extract in cancercells revealed that modulation of cell cycle regulators occurs upon treatment. As well asinducing apoptotic players such as TRAIL in cancer systems, anthocyanin extract inhibitedAkt-mTOR signalling thereby inducing maturation of acute myeloid leukaemia cells. Theseresults are of interest in view of the impact on food consumption and as functional foodcomponents on potential cancer treatment and prevention.