This chapter describes how disorder in pharmaceutical systems can be studied by means of Solid State NMR (SSNMR). It is organised in four parts: first, an elementary introduction to the basics of SSNMR is given for non-specialists; the two subsequent sections describe how static and dynamic disorder in pharmaceuticals can be studied by means of SSNMR; finally, the case study of Na-ibuprofen, where most of the concepts previously presented have been experimentally exploited, is illustrated in detail.
Study of disorder by solid-state NMR spectroscopy
Marco Geppi;Silvia Borsacchi;
2016
Abstract
This chapter describes how disorder in pharmaceutical systems can be studied by means of Solid State NMR (SSNMR). It is organised in four parts: first, an elementary introduction to the basics of SSNMR is given for non-specialists; the two subsequent sections describe how static and dynamic disorder in pharmaceuticals can be studied by means of SSNMR; finally, the case study of Na-ibuprofen, where most of the concepts previously presented have been experimentally exploited, is illustrated in detail.File in questo prodotto:
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