Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin, Two sets of functionalized azabicycloalkanes have been examined. In vitro as-says established that 21 has a good affinity specifically for alpha(v)beta(3).
Nonpeptide Integrin Antagonists: RGD Mimetics Incorporating Substituted Azabicycloalkanes as Amino Acid Replacements
2007
Abstract
Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin, Two sets of functionalized azabicycloalkanes have been examined. In vitro as-says established that 21 has a good affinity specifically for alpha(v)beta(3).File in questo prodotto:
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