We investigated the hyperthermic efficiency of two nanoconstructs, one, NPs@HFt, realized by growing ferrite nanoparticles within human H-chain ferritin shells, the other, HFt-NPs, by conjugation of magnetite nanoparticles with apo-HFt. In vitro tests showed that a 5% Co doping was necessary to induce highly reduce the cell viability in NPs@HFt, while the same treatment performed with HFt-NPs had no effect, despite its much larger hyperthermic performances. The different efficiency, related to a different level of cell internalization, points out the fundamental role of cell-nanoparticles interactions with respect to high hyperthermic efficiency. Research funded by projects RINAME-MIUR, CARIPLO n.2013-0752 and MAGNANO.
H-Ferritin-based Multifunctional Nanoparticles for Magnetic fluid Hyperthermia
E Falvo;P Ceci
2015
Abstract
We investigated the hyperthermic efficiency of two nanoconstructs, one, NPs@HFt, realized by growing ferrite nanoparticles within human H-chain ferritin shells, the other, HFt-NPs, by conjugation of magnetite nanoparticles with apo-HFt. In vitro tests showed that a 5% Co doping was necessary to induce highly reduce the cell viability in NPs@HFt, while the same treatment performed with HFt-NPs had no effect, despite its much larger hyperthermic performances. The different efficiency, related to a different level of cell internalization, points out the fundamental role of cell-nanoparticles interactions with respect to high hyperthermic efficiency. Research funded by projects RINAME-MIUR, CARIPLO n.2013-0752 and MAGNANO.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
