A convenient "one-pot" Friedel-Crafts reaction of mono-, bi- and tert-thiophenes with trifluoroacetic acid anhydride (TFAA) as an acylating agent and magnesium perchlorate dihydrate (anhydron) as catalyst affords trifluoroacetyl-substituted products in high yields. This method provides a novel approach for the synthesis of thiophene based derivatives bearing trifluoroacetyl group. The mechanism of this reaction is suggested.
Direct trifluoroacetylation of mono- and disubstituted thiophene derivatives
Erika Kozma;
2015
Abstract
A convenient "one-pot" Friedel-Crafts reaction of mono-, bi- and tert-thiophenes with trifluoroacetic acid anhydride (TFAA) as an acylating agent and magnesium perchlorate dihydrate (anhydron) as catalyst affords trifluoroacetyl-substituted products in high yields. This method provides a novel approach for the synthesis of thiophene based derivatives bearing trifluoroacetyl group. The mechanism of this reaction is suggested.File in questo prodotto:
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2015_JFluorineChem_Direct trifluoroacetylation of thiophene derivatives.pdf
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