Transition metal ion complexes of a number of chelators have been widely investigated due to their biological properties. The sugar conjugation of metal complexes has resulted in improved properties of the systems, such as solubility and lectin recognition. In this paper, we report the synthesis, the characterization of new glucose and galactose conjugates of 1,4,8,11-tetraazacyclotetradecane (cyclam) and their Cu<sup>II</sup> complexes. The glycoconjugates were proved to be protective agents of metal-induced amyloid aggregation. The binding constants of the galactose conjugate K<inf>A1</inf> =(3.07±0.16)×10<sup>7</sup> and K<inf>A2</inf> =(2.13±0.04)×10<sup>7</sup> M<sup>-1</sup> with the lectin Ricinus communis agglutinin (RCA<inf>120</inf>) as a model of galactose-specific human lectin were obtained with surface plasmon resonance.

Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation

Lanza Valeria;Bellia Francesco;Spoto Giuseppe;Spoto Giuseppe;
2015

Abstract

Transition metal ion complexes of a number of chelators have been widely investigated due to their biological properties. The sugar conjugation of metal complexes has resulted in improved properties of the systems, such as solubility and lectin recognition. In this paper, we report the synthesis, the characterization of new glucose and galactose conjugates of 1,4,8,11-tetraazacyclotetradecane (cyclam) and their CuII complexes. The glycoconjugates were proved to be protective agents of metal-induced amyloid aggregation. The binding constants of the galactose conjugate KA1 =(3.07±0.16)×107 and KA2 =(2.13±0.04)×107 M-1 with the lectin Ricinus communis agglutinin (RCA120) as a model of galactose-specific human lectin were obtained with surface plasmon resonance.
2015
Istituto di Biostrutture e Bioimmagini - IBB - Sede Napoli
Istituto di Cristallografia - IC
Amyloid
Carbohydrates
Copper
Cyclam
Lectins
Surface plasmon resonance
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/305882
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