Besides the clinical relevance and the wide application of this technology, several problems remain to be addressed.
Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks.
Microarrays as a tool for gene expression profiling: Application in ocular and craniofacial research
Torino Claudia;
2007
Abstract
Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.