Purpose: Cyclopentolate Hydrochloride (CYP) is widely used as mydriatic and cycloplegic agent. The product is marketed in the racemic form, an equimolar mixture of the two enantiomers (+) and (-) Cyclopentolate. The aim of our study was the development of an enantio-separation methodology, the preparation of two ophthalmic formulation based on (+) CYP (MDV-D) and (-) CYP (MDV-L) as well as the evaluation of their mydriatic activity in rabbits.
Enantiomeric Separation, Ophthalmic Formulations and Mydriatic Activity Of Cyclopentolate Hydrochloride
D'Antona N;Nicolosi G
2013
Abstract
Purpose: Cyclopentolate Hydrochloride (CYP) is widely used as mydriatic and cycloplegic agent. The product is marketed in the racemic form, an equimolar mixture of the two enantiomers (+) and (-) Cyclopentolate. The aim of our study was the development of an enantio-separation methodology, the preparation of two ophthalmic formulation based on (+) CYP (MDV-D) and (-) CYP (MDV-L) as well as the evaluation of their mydriatic activity in rabbits.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
