A novel MICA allele, MICA*078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA*078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G -> A), resulting in one amino acid change at codon 142 (V -> I) of MICA gene (compared to MICA*002:01), located in the alpha 2-domain, in which V142 is the common residue. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
MICA*078: A novel allele identified in a Moroccan individual affected by celiac disease
Piancatelli D;Del Beato T;Colanardi A;Sebastiani P;
2015
Abstract
A novel MICA allele, MICA*078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA*078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G -> A), resulting in one amino acid change at codon 142 (V -> I) of MICA gene (compared to MICA*002:01), located in the alpha 2-domain, in which V142 is the common residue. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.File in questo prodotto:
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