The substrate scope of the old yellow enzyme catalyzed reduction of -alkyl--arylnitroalkenes is investigated. Compounds bearing either alkyl chains of increasing length at the carbon atom in position to the nitro group or different substituents on the aromatic ring are prepared and submitted to bioreduction, to define the synthetic potential of this enantioselective reaction in the preparation of chiral fine chemicals. The versatility of the resulting nitroalkanes as chiral building blocks is shown by reducing the nitro group into a primary amine and by converting it into a carboxylic acid moiety by Meyer reaction.
Substrate Scope Evaluation of the Enantioselective Reduction of -Alkyl--arylnitroalkenes by Old Yellow Enzymes 1-3 for Organic Synthesis Applications
Monti Daniela;
2016
Abstract
The substrate scope of the old yellow enzyme catalyzed reduction of -alkyl--arylnitroalkenes is investigated. Compounds bearing either alkyl chains of increasing length at the carbon atom in position to the nitro group or different substituents on the aromatic ring are prepared and submitted to bioreduction, to define the synthetic potential of this enantioselective reaction in the preparation of chiral fine chemicals. The versatility of the resulting nitroalkanes as chiral building blocks is shown by reducing the nitro group into a primary amine and by converting it into a carboxylic acid moiety by Meyer reaction.File in questo prodotto:
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