A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3Ò-hydroxy-5Ñ-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethyleneglycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport
C2-symmetrical sterol-polyether conjgates as highly efficient synthetic ionophores
2003
Abstract
A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3Ò-hydroxy-5Ñ-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethyleneglycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transportFile in questo prodotto:
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