Amiloride derivatives represent a class of new promising chemotherapeutic agents. A representative member belonging to this family is the sodium-hydrogen antiporter inhibitor HMA (5-(N,N-hexamethylene amiloride), which modulates pH inducing cellular intracytosolic acidification. We characterized the response to HMA on human cell lines, observing that HMA is able to induce alterations of cell metabolism.
Modulation of intracellular pH in cancer cells drives multiple cell death pathways.
Scovassi A
2015
Abstract
Amiloride derivatives represent a class of new promising chemotherapeutic agents. A representative member belonging to this family is the sodium-hydrogen antiporter inhibitor HMA (5-(N,N-hexamethylene amiloride), which modulates pH inducing cellular intracytosolic acidification. We characterized the response to HMA on human cell lines, observing that HMA is able to induce alterations of cell metabolism.File in questo prodotto:
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