Benzylic Amide Rotaxanes: A Versatile Architecture

In the last few decades, much effort has been dedicated to the developing of such interlocked architectures, which can be subjected to different types of submolecular motion. The field of Rotaxanes has evolved to stimuli-responsive molecular shuttle, capable of responding to several different external stimuli. The interest in molecular shuttles arises from the possibility of achieving controlled submolecular motion of their components with respect to one another.

Rotaxanes are currently seen as one of the most promising components in artificial molecular machines.