The investigation is related to the development of a general strategy for the synthesis of glycolipids including analogs bearing polyunsaturated fatty acids. In particular, here we report exceptionally mild and selective conditions to remove acetate protecting groups from glyceroglycolipids by hydrazinolysis. Synthetic 1,2-O-di-arachidonoyl-3-O-beta-galactosyl-glycerol was used as representative of polyunsaturated beta-galactosyl-di-acyl-glycerols due to its reactivity under the conditions usually employed in literature.
Glycolipids synthesis: improved hydrazinolysis conditions for preparation of 1,2-polyunsaturated fatty acyl-beta-monogalactosyl-glycerols
Dario Pagano;Adele Cutignano;Emiliano Manzo;Francesco Tinto;Angelo Fontana
2016
Abstract
The investigation is related to the development of a general strategy for the synthesis of glycolipids including analogs bearing polyunsaturated fatty acids. In particular, here we report exceptionally mild and selective conditions to remove acetate protecting groups from glyceroglycolipids by hydrazinolysis. Synthetic 1,2-O-di-arachidonoyl-3-O-beta-galactosyl-glycerol was used as representative of polyunsaturated beta-galactosyl-di-acyl-glycerols due to its reactivity under the conditions usually employed in literature.File in questo prodotto:
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