The VDAC (Voltage Dependent Anion selective Channel) family of proteins is composed of three evolutionary related isoforms in vertebrates [1-2]. Despite the sequence similarity, the functional data existing nowadays point to different functions for them. The isoforms are expressed at different levels [3], and show a different ability to complement the growth defect in yeast S. cerevisiae devoid of the endogenous porin [4], indicating that either they have different capacities to be translocated in the OMM or they have really different pore-forming activity, at least when expressed in S.
Preliminary Characterization of VDAC3, an Elusive Member of the Outer Mitochondrial Membrane Pore Family
Matteo Ceccarelli;
2015
Abstract
The VDAC (Voltage Dependent Anion selective Channel) family of proteins is composed of three evolutionary related isoforms in vertebrates [1-2]. Despite the sequence similarity, the functional data existing nowadays point to different functions for them. The isoforms are expressed at different levels [3], and show a different ability to complement the growth defect in yeast S. cerevisiae devoid of the endogenous porin [4], indicating that either they have different capacities to be translocated in the OMM or they have really different pore-forming activity, at least when expressed in S.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
