Lorentz force study on the interparticle dipolar interactions between nanoparticles for magnetic hyperthermia

Magnetic nanoparticles are considered key nanomaterials for future information storage, energy and biomedical and pharmaceutical applications. In particular in the biomedicine, they are suitable for both diagnostics, therapeutics and delivery. They are proposed as contrast agents to enhance the magnetic resonance imaging signal, while in the field of therapeutics, they can be used as magnetic vectors in drug delivery and/or as heat mediators in hyperthermia treatment. In this last application, the apoptosis of cancer cells is produced by the local increase of the temperature thanks to the heating of the magnetic nanoparticles contained in the cells under a oscillating magnetic fields. The physic-chemical mechanisms and effects that give rise to the magnetic energy losses are under study. One of the most discussed questions is the role of the interparticle interactions induced by the different aggregation levels, which can be different in the laboratory conditions and into the cells.