Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu2+ or Zn2+, altering the metallostasis of cancer cells, leading to their death.
Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration
F Bellia;Enrico Rizzarelli
2016
Abstract
Carnosine derivative containing liposomes functionalized with the Fab' fragment of Trastuzumab were synthesized. They represent a new class of antibody-drug conjugates because carnosine acts as an ionophore for Cu2+ or Zn2+, altering the metallostasis of cancer cells, leading to their death.File in questo prodotto:
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