Starting with the needs of laboratory mice, the presentation will then focus on the needs of genetically engineered mice. These mice are often specifically created to model human diseases and in some cases they can inevitably present with potential welfare issues. In particular, models of neurological and psychiatric disorders will be considered, and examples of procedures aimed at the evaluation of mouse neurodevelopment, reflexes, sensory and motor functions as well as other neurobehavioural phenotypes will be illustrated. Finally, examples and recommendations on how to cope with welfare issues in genetically altered mice will be described.
Taking into account the needs of genetically engineered animals to improve animal welfare.
Silvia Mandillo
2016
Abstract
Starting with the needs of laboratory mice, the presentation will then focus on the needs of genetically engineered mice. These mice are often specifically created to model human diseases and in some cases they can inevitably present with potential welfare issues. In particular, models of neurological and psychiatric disorders will be considered, and examples of procedures aimed at the evaluation of mouse neurodevelopment, reflexes, sensory and motor functions as well as other neurobehavioural phenotypes will be illustrated. Finally, examples and recommendations on how to cope with welfare issues in genetically altered mice will be described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
