The EU has published her Action Plan in 2011 against the rising threats from antimicrobial resistance. Developing new antibiotics is mandatory but takes years. A short-term alternative is the development of novel strategies to deliver existing drugs in an optimized way. In this frame, the use of engineered antibiotic nanocarriers is one of the most promising options. The objective of our research in the frame of the ITN project Cyclonhit is to take full advantage of nanotechnology to efficiently encapsulate antibiotics in nanocarriers to kill both intracellular and extracellular bacteria. We have focused on two drugs, Ethionamide and Clofazimine, used for the treatment of TBC and Lepromatous Leprosy, respectively. Both suffer from very low solubility in water reducing drastically their bioavailability and complicating their administration. We have studied two different types of carrier systems consisting of polymeric cyclodextrins marked with fluorophores, on one hand, and porous fluorescent silica particles with size ranging from few hundreds of nm to 2 micrometers, on the other hand. We will discuss loading of the two drugs by these new fluorescent carrier systems, their antibacterial activity and their penetration in skin tissue.
New carrier systems for antibiotics delivery
Ilse Manet;
2016
Abstract
The EU has published her Action Plan in 2011 against the rising threats from antimicrobial resistance. Developing new antibiotics is mandatory but takes years. A short-term alternative is the development of novel strategies to deliver existing drugs in an optimized way. In this frame, the use of engineered antibiotic nanocarriers is one of the most promising options. The objective of our research in the frame of the ITN project Cyclonhit is to take full advantage of nanotechnology to efficiently encapsulate antibiotics in nanocarriers to kill both intracellular and extracellular bacteria. We have focused on two drugs, Ethionamide and Clofazimine, used for the treatment of TBC and Lepromatous Leprosy, respectively. Both suffer from very low solubility in water reducing drastically their bioavailability and complicating their administration. We have studied two different types of carrier systems consisting of polymeric cyclodextrins marked with fluorophores, on one hand, and porous fluorescent silica particles with size ranging from few hundreds of nm to 2 micrometers, on the other hand. We will discuss loading of the two drugs by these new fluorescent carrier systems, their antibacterial activity and their penetration in skin tissue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
