In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 ?M), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the ?-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.
Model of murine ventricular cardiac tissue for in vitro kinematic-dynamic studies of electromagnetic and ?-adrenergic stimulation
Pellegrini M;
2017
Abstract
In a model of murine ventricular cardiac tissue in vitro, we have studied the inotropic effects of electromagnetic stimulation (frequency, 75 Hz), isoproterenol administration (10 ?M), and their combination. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of beating cardiac syncytia starting from the video registration of their contraction movement. We have found that the electromagnetic stimulation is able to counteract the ?-adrenergic effect of isoproterenol and to elicit an antihypertrophic response.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_382315-doc_129883.pdf
accesso aperto
Descrizione: Model of Murine Ventricular Cardiac Tissue for In Vitro Kinematic-Dynamic Studies of Electromagnetic and ?-Adrenergic Stimulation
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
2.37 MB
Formato
Adobe PDF
|
2.37 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
