Researchers present an in-depth review on the contribution of biophysical and biochemical studies and computer simulations to characterize the molecular structures of A?1-40/1-42 monomers, oligomers, protofibrils, and amyloid fibrils in aqueous solution. They focus their current knowledge of the A?1-40/1-42 nucleus and the structures and dynamics of A?1-40/1-42 oligomers in proximity of or at the membrane. They also the available information regarding the interactions of A? monomers and oligomers with ion metals, cellular partners, and potential inhibitors.
Amyloid beta Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies
Melchionna Simone;
2015
Abstract
Researchers present an in-depth review on the contribution of biophysical and biochemical studies and computer simulations to characterize the molecular structures of A?1-40/1-42 monomers, oligomers, protofibrils, and amyloid fibrils in aqueous solution. They focus their current knowledge of the A?1-40/1-42 nucleus and the structures and dynamics of A?1-40/1-42 oligomers in proximity of or at the membrane. They also the available information regarding the interactions of A? monomers and oligomers with ion metals, cellular partners, and potential inhibitors.File in questo prodotto:
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