Correlation between obesity, Irisin and glycemia

Obesity is a multifactorial disease that involves a series of metabolic dysregulation and the possibility of differentiating adipose stem cells from white fat to brown fat to induce a thermogenic activation and increased energy expenditure which is currently considered as a major promising approach to combat obesity and its complications. A new miochina "irisina" which decrypts active metabolic white fat and turns it into brown fat. This molecule was originally developed because it was released in the course of physical activity. The Irisina (112 amino acids) is a protein fibronectin type III that was out of the proteolytic cleavage of the FNDC5 protein (Fibronectin Domain-Containing Protein 5) which seems to respond positively to exercise. The evaluation of this miochina that seems not to correlate with the nutritional regime is of extreme importance as to date there are few analysis systems sensitive enough to detect it. The purpose of our study was to examine a cohort of individuals (age range 30-70) in good health by relating the main parameters of blood count, clinical chemistry and oxidative stress with the amount of circulating Irisina. Subjects were grouped by age, gender and physical activity. The first results showed consistent correlation between the increase in oxidative stress with age and a lower concentration of Irisina. In normoglycemic subjects we found an interesting correlation with blood glucose levels and an increase in oxidative stress levels.