A genome-wide association study of educational attainment was conducted in a discovery sampleof 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effectssizes are small (R2? 0.02%), approximately 1 month of schooling per allele. A linear polygenicscore from all measured SNPs accounts for ? 2% of the variance in both educational attainmentand cognitive function. Genes in the region of the loci have previously been associated withhealth, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest theinvolvement of the anterior caudate nucleus. These findings provide promising candidate SNPs forfollow-up work, and our effect size estimates can anchor power analyses in social-sciencegenetics.
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
Marco Masala;
2013
Abstract
A genome-wide association study of educational attainment was conducted in a discovery sampleof 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effectssizes are small (R2? 0.02%), approximately 1 month of schooling per allele. A linear polygenicscore from all measured SNPs accounts for ? 2% of the variance in both educational attainmentand cognitive function. Genes in the region of the loci have previously been associated withhealth, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest theinvolvement of the anterior caudate nucleus. These findings provide promising candidate SNPs forfollow-up work, and our effect size estimates can anchor power analyses in social-sciencegenetics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
