CRD detected allergen hypersensitivity in 87.6% of patients with EoE. The predominant allergens were grass group 1 (55%), lipid transfer proteins (LTP) of peach and mugwort, hazelnuts and walnuts. Callose from pollen tubes was found in 65·6 % of biopsies. After CRD-guided elimination diet and/or AIT, 101 (78·3%) EoE patients showed significant clinical improvement (p<0·017) and 97 (75·2%) were discharged (negative biopsy, no symptoms, no medication) without relapse. AIT-treated patients had better outcomes (odds ratio 177·3, 95% CI 16·2-1939·0). CRD-directed AIT and/or elimination diet was efficient in treating EoE patients and was well tolerated.
Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis
2017
Abstract
CRD detected allergen hypersensitivity in 87.6% of patients with EoE. The predominant allergens were grass group 1 (55%), lipid transfer proteins (LTP) of peach and mugwort, hazelnuts and walnuts. Callose from pollen tubes was found in 65·6 % of biopsies. After CRD-guided elimination diet and/or AIT, 101 (78·3%) EoE patients showed significant clinical improvement (p<0·017) and 97 (75·2%) were discharged (negative biopsy, no symptoms, no medication) without relapse. AIT-treated patients had better outcomes (odds ratio 177·3, 95% CI 16·2-1939·0). CRD-directed AIT and/or elimination diet was efficient in treating EoE patients and was well tolerated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
