The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), Is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM Interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274, and D6S259, 5 - 6 cM apart. A single rare four marker haplotype within this Interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 In five kindreds originating from this area. © 1993 Oxford University Press.
The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci
Frontali Marina;Frontali Marina;
1993
Abstract
The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), Is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM Interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274, and D6S259, 5 - 6 cM apart. A single rare four marker haplotype within this Interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 In five kindreds originating from this area. © 1993 Oxford University Press.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.