A formal synthesis of podophyllotoxin was carried out in nine steps. The key pseudo-domino step was accomplished through the succession of an intermolecular palladium-catalyzed allylic alkylation and an intramolecular Mizoroki-Heck coupling reaction.
Pseudo-Domino Palladium-Catalyzed Allylic Alkylation/Mizoroki-Heck Coupling Reaction: A Key sequence toward (±)-Podophyllotoxin
F Mingoia;
2008
Abstract
A formal synthesis of podophyllotoxin was carried out in nine steps. The key pseudo-domino step was accomplished through the succession of an intermolecular palladium-catalyzed allylic alkylation and an intramolecular Mizoroki-Heck coupling reaction.File in questo prodotto:
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