Dystroglycan (DG) is an adhesion complex formed by two subunits, ?-DG and ?-DG. In skeletal muscle, DG is part of the dystrophin-glycoprotein complex that is crucial for sarcolemma stability and it is involved in a plethora of muscular dystrophy phenotypes. Due to the important role played by DG in skeletal muscle stability as well as in a wide variety of other tissues including brain and the peripheral nervous system, it is essential to investigate its genetic assembly and transcriptional regulation.
Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene
F Sciandra;A Brancaccio
2017
Abstract
Dystroglycan (DG) is an adhesion complex formed by two subunits, ?-DG and ?-DG. In skeletal muscle, DG is part of the dystrophin-glycoprotein complex that is crucial for sarcolemma stability and it is involved in a plethora of muscular dystrophy phenotypes. Due to the important role played by DG in skeletal muscle stability as well as in a wide variety of other tissues including brain and the peripheral nervous system, it is essential to investigate its genetic assembly and transcriptional regulation.File in questo prodotto:
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