A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4-hydroxybutanoic acid derived linker (Scheme 2). © 2005 Verlag Helvetica Chimica Acta AG, Zürich.
A new and simply available class of hydrosoluble bioconjugates by coupling paclitaxel to hyaluronic acid through a 4-hydroxybutanoic acid derived linker
Capodilupo Agostina Lina;Capodilupo Agostina Lina;
2005
Abstract
A simple preparation of a new hydrosoluble paclitaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described. Bioconjugate 8 was obtained by coupling hyaluronic acid (2) to paclitaxel (1) by means of a 4-hydroxybutanoic acid derived linker (Scheme 2). © 2005 Verlag Helvetica Chimica Acta AG, Zürich.File in questo prodotto:
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