Polymer based nanoparticles (NPs) are an emerging strategy in disease treatment due to the advantage to manipulate their properties by selecting polymer type and tuning the carrier assembly. For a rational design of NPs, the particle size and chemical surface properties of the nanocarriers are relevant to control NP interaction with body environment in order to give asuccessful application. For example, PEGylated NPs are able to evade MPS and allow a long circulation. Recently, cationic NPs are in the limelight as a possible nanocarrier in cancer due to their unique ability to penetrate deeply inside tumor tissue and to interact preferentially with plasma membrane of cancer cells. To this purpose, here we have developed an array of cationic NPs based on an amino-terminated poly(?-caprolactone) (PCL4.2k-NH2) mixed with polyethylenglycol-poly(?-caprolactone) (mPEG1k-PCL4k) with different charge density and surface hydrophilicity. In order to improve stability and to impart targeting properties, NPs have been decorated with a layer of low molecular weight hyaluronic acid (HA) which can encourage NPs uptake in cell overexpressing CD44 receptors.
Cationic poly( e - caprolactone) nanoparticles as versatile scaffolds for cancer therapy
G Dal Poggetto;P Laurienzo;
2018
Abstract
Polymer based nanoparticles (NPs) are an emerging strategy in disease treatment due to the advantage to manipulate their properties by selecting polymer type and tuning the carrier assembly. For a rational design of NPs, the particle size and chemical surface properties of the nanocarriers are relevant to control NP interaction with body environment in order to give asuccessful application. For example, PEGylated NPs are able to evade MPS and allow a long circulation. Recently, cationic NPs are in the limelight as a possible nanocarrier in cancer due to their unique ability to penetrate deeply inside tumor tissue and to interact preferentially with plasma membrane of cancer cells. To this purpose, here we have developed an array of cationic NPs based on an amino-terminated poly(?-caprolactone) (PCL4.2k-NH2) mixed with polyethylenglycol-poly(?-caprolactone) (mPEG1k-PCL4k) with different charge density and surface hydrophilicity. In order to improve stability and to impart targeting properties, NPs have been decorated with a layer of low molecular weight hyaluronic acid (HA) which can encourage NPs uptake in cell overexpressing CD44 receptors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
