A series of bis- and tris-ligated 3,7-dimethyl-1,3,5-triaza-7-phosphabicyclo[3.3.1]nonane (PTN(Me)) silver(I) complexes featuring different types of counterions, including the antibiotic triclosan, were synthesized and fully characterized. For comparison, the bis-PTN(Me) gold species was re-prepared. Density functional theory modeling revealed strong Ag-P bonding and negligible Ag-N interactions. All complexes were assessed for antimicrobial activity against Gram-negative and Gram-positive bacteria, and fungi. The highest activity was against the Gram-negative Escherichia coli bacteria, particularly by complexes featuring the triclosan counterion.
Water-Soluble Silver(I) Complexes Featuring the Hemilabile 3,7-Dimethyl-1,3,5-triaza-7-phosphabicyclo[3.3.1]nonane Ligand: Synthesis, Characterization, and Antimicrobial Activity
Antonella Guerriero;Maurizio Peruzzini;Luca Gonsalvi;
2018
Abstract
A series of bis- and tris-ligated 3,7-dimethyl-1,3,5-triaza-7-phosphabicyclo[3.3.1]nonane (PTN(Me)) silver(I) complexes featuring different types of counterions, including the antibiotic triclosan, were synthesized and fully characterized. For comparison, the bis-PTN(Me) gold species was re-prepared. Density functional theory modeling revealed strong Ag-P bonding and negligible Ag-N interactions. All complexes were assessed for antimicrobial activity against Gram-negative and Gram-positive bacteria, and fungi. The highest activity was against the Gram-negative Escherichia coli bacteria, particularly by complexes featuring the triclosan counterion.| File | Dimensione | Formato | |
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prod_387697-doc_133433.pdf
Open Access dal 23/05/2019
Descrizione: “This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, copyright © 2018 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.inorgchem.8b00227."
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Inorg. Chem., 2018, 57, 6309–6323.pdf
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