Objective: The regulation of glucose and adipose tissue metabolism by GLP1-receptor agonist is a possible treatment of T2D and obesity. These new pharmacologic agents target insulin resistance and metabolic disorders. Methods: Eighteen patients, 7 males and 11 females, were studied with T2D, divided into two groups: the first (I) was poorly controlled by metformin and sulfonylureas; the second (II) was treated only with metformin. Exenatide was administered at an initial dose of 5 ?g twice a day for one month, and then the dose was adjusted to 10 ?g twice a day throughout 24-26 weeks. From the beginning of therapy, each group was analyzed at time 0 and at 1 month (T1) and then 6 months (T2). At every time, anthropometric data, body composition by DXA and biochemical parameters were recorded. Results: At baseline, all patients enrolled showed metabolic disorders and obesity. The comparison of both groups between baseline and T2 showed a significant decrease of body weight, total Fat Mass (FM) and HbA1c (%), only in group (I) a statical reduction of Glycaemia and Total Cholesterol was observed. The Free Fat Mass (FFM) was never seen significantly different. The patients with HbA1c levels >75 mmol/mol (9%) at baseline showed a greater decline of HbA1c when compared to the patients with HbA1c <75 mmol/mol. Conclusion: Exenatide improves glucose metabolism and total cholesterol levels. Moreover, Exenatide reduced total FM and did not affect FFM. Exenatide could be used to treat obesity in diabetic but also non-diabetic patients. Summary: Exenatide, a GLP1-receptor agonist, is a pharmacological agent against obesity and type 2 diabetes mellitus. Exenatide decreases insulin resistance and lipids metabolism, and could be able to reduce fat mass and cardiovascular risk.

Effects of Exenatide on both fat mass loss and cardiometabolic risk in obese subjects with type 2 diabetes mellitus

Carmela Colica;
2017

Abstract

Objective: The regulation of glucose and adipose tissue metabolism by GLP1-receptor agonist is a possible treatment of T2D and obesity. These new pharmacologic agents target insulin resistance and metabolic disorders. Methods: Eighteen patients, 7 males and 11 females, were studied with T2D, divided into two groups: the first (I) was poorly controlled by metformin and sulfonylureas; the second (II) was treated only with metformin. Exenatide was administered at an initial dose of 5 ?g twice a day for one month, and then the dose was adjusted to 10 ?g twice a day throughout 24-26 weeks. From the beginning of therapy, each group was analyzed at time 0 and at 1 month (T1) and then 6 months (T2). At every time, anthropometric data, body composition by DXA and biochemical parameters were recorded. Results: At baseline, all patients enrolled showed metabolic disorders and obesity. The comparison of both groups between baseline and T2 showed a significant decrease of body weight, total Fat Mass (FM) and HbA1c (%), only in group (I) a statical reduction of Glycaemia and Total Cholesterol was observed. The Free Fat Mass (FFM) was never seen significantly different. The patients with HbA1c levels >75 mmol/mol (9%) at baseline showed a greater decline of HbA1c when compared to the patients with HbA1c <75 mmol/mol. Conclusion: Exenatide improves glucose metabolism and total cholesterol levels. Moreover, Exenatide reduced total FM and did not affect FFM. Exenatide could be used to treat obesity in diabetic but also non-diabetic patients. Summary: Exenatide, a GLP1-receptor agonist, is a pharmacological agent against obesity and type 2 diabetes mellitus. Exenatide decreases insulin resistance and lipids metabolism, and could be able to reduce fat mass and cardiovascular risk.
2017
Istituto di Bioimmagini e Fisiologia Molecolare - IBFM
exenatide
GLP1-receptor agonist
diabetes mellitus
obesity
FM
FFM
cholesterol
HbA1c
DXA
cardiometabolic
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.14243/346364
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact