In a previous paper, we reported that the fine control of the solvent evaporation rate in membrane crystallizers allows us to modulate the rate of achievement of supersaturation. This induced the selective crystallization of either stable or metastable polymorph of glycine, by switching between a thermodynamic and a kinetic control of the nucleation stage. Here, we studied the polymorphic yield of the membrane crystallized paracetamol.
Controlling polymorphism with membrane-based crystallizers: application to form I and II of paracetamol
Di Profio G;Curcio E;Drioli E
2007
Abstract
In a previous paper, we reported that the fine control of the solvent evaporation rate in membrane crystallizers allows us to modulate the rate of achievement of supersaturation. This induced the selective crystallization of either stable or metastable polymorph of glycine, by switching between a thermodynamic and a kinetic control of the nucleation stage. Here, we studied the polymorphic yield of the membrane crystallized paracetamol.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_54905-doc_43955.pdf
non disponibili
Descrizione: Controlling polymorphism with membrane-based crystallizers: application to form I and II of paracetamol
Tipologia:
Versione Editoriale (PDF)
Dimensione
126.02 kB
Formato
Adobe PDF
|
126.02 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
