MicroRNAs, small molecules of 22-25 nt, inhibit translation of target mRNAs and with transcription factors comprise two major layers of gene regulatory networks with strictly intercon- nected activities. Tbx5, a dosage sensitive gene, is a pivotal player involved in heart/limbs development and its mutations are responsi- ble of the Holt-Oram syndrome (HOS) in human, characterized by upper limb malformations and congenital heart defects (CHD)s both in morphology and electrophysiology.
MIR-182 is a Tbx5 effector during heart development in zebrafish
Guzzolino E;D'aurizio R;Mercatanti A;Evangelista M;Pitto L
2018
Abstract
MicroRNAs, small molecules of 22-25 nt, inhibit translation of target mRNAs and with transcription factors comprise two major layers of gene regulatory networks with strictly intercon- nected activities. Tbx5, a dosage sensitive gene, is a pivotal player involved in heart/limbs development and its mutations are responsi- ble of the Holt-Oram syndrome (HOS) in human, characterized by upper limb malformations and congenital heart defects (CHD)s both in morphology and electrophysiology.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
prod_388524-doc_133773.pdf
solo utenti autorizzati
Descrizione: mir
Tipologia:
Versione Editoriale (PDF)
Dimensione
57.91 kB
Formato
Adobe PDF
|
57.91 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
