An integrated metabolism, growth and cell cycle model quantitatively describing budding yeast growth

Computational models are expected to increase the understanding of how complex biological functions arise from the interactions of large numbers of gene products and biologically active low molecular weight molecules. Recent studies underline the need to develop quantitative models of the whole cell in order to tackle this challenge and to accelerate biological discoveries. In this work we describe iMeGroCy, an integrated model of the three major functions of a yeast cell: Metabolism, Growth and Cycle. The MeGro (Metabolism and Growth) and GroCy (Growth and Cycle) modules are linked together in a unified, low granularity model where MeGro acts as a parameter generator for GroCy. The model can be used as a scaffold for molecularly detailed models of yeast functions