From PTA to novel CAP: application of water soluble phosphines in catalysis and medicinal chemistry

The oral communication has been focused on the scientific results obtained in the last years in the chemistry of water soluble phosphines indicated with the acronyms of PTA and CAP. The first part of the presentation has been dedicated to the description of the synthetic modification of PTA (upper and lower rim derivatization) and the synthesis of the corresponding transition metal complexes, in particular ruthenium, iridium and rhodium derivatives. The results obtained in numerous catalytic tests of hydrogenations and hydroformylations, both under homogeneous and heterogeneous conditions, have also been described. The second part of the presentation has been reserved to the very last results obtained in the coordination chemistry of CAP, the higher homologue of PTA only recently appeared in the literature, and its use in catalysis and in medicinal chemistry. The communication has been concluded with the description of the future perspectives of the research project.