Effect of PM10 chemical components on mRNA stability and processing

The air pollution is a global threat for ecosystems and, as a consequence , for human health. The atmpspheric contamination can have an impact on biological system, primarly humans, through two different routes:by direct inhalation of pollutant mixtures; by food or water contaminated by atmospheric events (rain, snow, wind). The synergistic actions of two exposure ways contributes to the overall stress. Integrated approches combining molecular biology, epidemiological and socio-economic information have allowed to face the problem of long term exposure in a more comprehensive way. This relative new approche, called "exposome", is focused on a deep investigation of effect of multiple pollution sources on the individual health. In the last decade NGS techniques. including RNA-seq, have turned up the roles of RNAs on the response against environmental, biological or chemical-physics stress factors. In term of environmental toxixology the effect on tranlational and RNA degradation processes can occur even in the case of low level exposure applied for long time. Among contaminants that could impact the functionallity of different RNAs, the particulate matter actually are probably the widely studied. In a previous paper we have considered the interactions between pollutants and ncRNAs. Here we analysed the potential interaction of PM10 chemical components on RNA regulatory components (Poly-A sites, Au-rich and M6A). located in the 3utr of target genes. The initial data were obtained froman environmental and epidemiological survey in Koradi (Maharashtra) area. This analysis suggest that organic compound can influence the mRNAprocessing pathway altering the protein-nucleic acid recognition