Previously we showed an interesting effectiveness of the electromagnetic information delivery of a specific source molecule in mimicking its specific biological effect. Nevertheless the effect was quite lower than the original positive control. Therefore we decide to assess a possible synergism between a reduced dose of a molecule and its own electromagnetic information in order to increase the efficacy of this procedure trying to disclose new possible avenues in translational pharmacology following suggestion from other works reporting synergistic effect between molecules and extremely low frequency electromagnetic fields. A reduced dose of retinoic acid, corresponding to a tenth of the usual, was delivered together with its own electromagnetic information to LAN-5 neuroblatoma cells. The signals from retinoic acid molecules was transferred to the cell culture medium employing as for our previous reports a commercial available electro medical device (Vegaselect 719). The effect on cell differentiation was significantly higher, and statistically significant, than the one obtained by the electromagnetic information delivery procedure when performed alone. A positive and effective synergism between a reduced drug dose and its own electromagnetic information seems to emerge as a promising and useful perspective in translational pharmacology outlining future applications in new drug delivery protocols allowing to reduce the amount of drug's doses especially in the elderly and in the increasing number of patients with multiple comorbidities. Bioelectromagnetic and biochemistry should, therefore, be considered on the way of a promising wedding instead of a permanently independent life. Future researches should either optimize the protocols of preparation of these potentially new drugs, either assess the lifespan of their biological effect in order to translate them into effective clinical application at the bedside through Biolectromagnetic medicine.
The wedding of bioelectromagnetic and biochemistry: Bridging a molecule and its own electromagnetic information
Ledda M;Grimaldi S;Lisi A
2015
Abstract
Previously we showed an interesting effectiveness of the electromagnetic information delivery of a specific source molecule in mimicking its specific biological effect. Nevertheless the effect was quite lower than the original positive control. Therefore we decide to assess a possible synergism between a reduced dose of a molecule and its own electromagnetic information in order to increase the efficacy of this procedure trying to disclose new possible avenues in translational pharmacology following suggestion from other works reporting synergistic effect between molecules and extremely low frequency electromagnetic fields. A reduced dose of retinoic acid, corresponding to a tenth of the usual, was delivered together with its own electromagnetic information to LAN-5 neuroblatoma cells. The signals from retinoic acid molecules was transferred to the cell culture medium employing as for our previous reports a commercial available electro medical device (Vegaselect 719). The effect on cell differentiation was significantly higher, and statistically significant, than the one obtained by the electromagnetic information delivery procedure when performed alone. A positive and effective synergism between a reduced drug dose and its own electromagnetic information seems to emerge as a promising and useful perspective in translational pharmacology outlining future applications in new drug delivery protocols allowing to reduce the amount of drug's doses especially in the elderly and in the increasing number of patients with multiple comorbidities. Bioelectromagnetic and biochemistry should, therefore, be considered on the way of a promising wedding instead of a permanently independent life. Future researches should either optimize the protocols of preparation of these potentially new drugs, either assess the lifespan of their biological effect in order to translate them into effective clinical application at the bedside through Biolectromagnetic medicine.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
