Objective: We aimed to study whether A beta O-42-induced mtDNA damage is involved in the regulation of stem cell differentiation.
Background: Amyloid-beta(42) oligomers (A beta O-42), the proximate effectors of neurotoxicity observed in Alzheimer's disease (AD), can induce mitochondrial oxidative stress and impair mitochondrial function besides causing mitochondrial DNA (mtDNA) damage. A beta O-42 also regulate the proliferative and differentiative properties of stem cells.
Amyloid-beta Oligomers-induced Mitochondrial DNA Repair Impairment Contributes to Altered Human Neural Stem Cell Differentiation
Mollinari Cristiana;
2019
Abstract
Background: Amyloid-beta(42) oligomers (A beta O-42), the proximate effectors of neurotoxicity observed in Alzheimer's disease (AD), can induce mitochondrial oxidative stress and impair mitochondrial function besides causing mitochondrial DNA (mtDNA) damage. A beta O-42 also regulate the proliferative and differentiative properties of stem cells.File in questo prodotto:
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