Protective effects of non-ionizing radiofrequency fields in mammalian cells damaged by mutagens

The acquired resistance by cells and organisms pre-exposed to low doses of ionizing radiation or selected genotoxic chemicals to the damaging effect of higher doses of the same or other agents, is commonly referred to as adaptive response (AR). It has been demonstrated in several cell types as well as in in vivo experiments, by measuring chromosomal and DNA damage, apoptosis, oxidative stress and survival. Despite a large amount of experimental results, several hypothesis have been proposed to explain this phenomenon but at the moment there is not yet an action mechanism universally accepted. Recently, our research group evidenced the capability of radiofrequency (RF) to offer protection against the effects of chemical and physical agents in different cell types, resembling the phenomenon of AR. Other research groups confirmed this observation also in in vivo studies. In this presentation, the results of RF-induced AR, collected so far, and the ongoing investigation aimed to characterize the phenomenon will be presented. Moreover, the potential action mechanisms involved in the RF-induced AR will be discussed.